CANCER IMMUNOTHERAPY WITH IMMUNE CHECKPOINT INHIBITORS-BIOMARKERS OF RESPONSE AND TOXICITY; CURRENT LIMITATIONS AND FUTURE PROMISE

Cancer Immunotherapy with Immune Checkpoint Inhibitors-Biomarkers of Response and Toxicity; Current Limitations and Future Promise

Immune checkpoint inhibitors are monoclonal antibodies that are used to treat over one in three cancer patients.While they have changed the natural history of disease, prolonging life and preserving quality of life, they are highly active in less than 40% of patients, Sodas even in the most responsive malignancies such as melanoma, and cause signif

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Internally-headed relative clauses in sign languages

This chapter considers relative clause data from sign languages in light of their variation with respect to basic word order, nonmanual marking, and presence/absence of internally-headed and externally-headed relative clauses.Syntactically, a double merge cartographic model (Cinque 2005a; b), following Brunelli (2011), is adopted.The differences ac

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